Dr. Shilpee Jain

Shilpee Jain

Ph.D., IIT Kanpur
Assistant Professor

Shilpee Jain

Ph.D., IIT Kanpur
shilpee.j@chanakyaversity.edu.in
Hyperthermia, Cancer therapeutics, Medical microrobots, Translational research, Tissue engineering, Magnetic nanomaterials, Carbon nanomaterials.

We are a team of bioengineers developing advanced micro- and nanodevices for diverse biomedical applications. Our current research primarily focuses on efficient intracellular delivery of biomolecules using external stimulations to achieve improved therapeutic outcomes.

A major area of our research is dedicated to developing novel therapeutic strategies for solid tumors, which remain a pressing global health challenge. This burden is particularly high in low- and middle-income countries, where access to effective treatments is limited. Despite the use of conventional approaches such as surgery, radiation therapy, and chemotherapy, clinical outcomes remain unsatisfactory, with 5-year survival rates stagnating at around 50–60%. These limitations underscore the urgent need for alternative, targeted therapies.

One promising avenue is Magnetic Hyperthermia Therapy (MHT), an emerging nanotechnology-based approach. In MHT, biocompatible magnetic nanoparticles are introduced into tumor tissue and exposed to an alternating magnetic field, generating localized heat to selectively kill cancer cells. This method offers high spatial precision, minimizes collateral tissue damage, improves patient comfort, and can be combined synergistically with existing therapies to overcome resistance mechanisms.

We are also exploring the use of micro/nanobots for targeted drug and biomolecule delivery. By applying external stimulations (such as electric or magnetic fields) and functionalizing these micro/nanobots, we can significantly enhance the precision, efficiency, and speed of delivering therapeutic agents to specific populations of cells. In addition, we are working on smart, biodegradable bandages for wound healing. These bandages not only support regenerated tissue but also accelerate recovery by providing controlled external electrical stimulation.

Dr. Shilpee Jain is an Assistant Professor at the School of Biosciences, Chanakya University. She received her PhD from the Indian Institute of Technology Kanpur, and her research primarily focuses on biomedical science and entrepreneurship, with expertise in hyperthermia, cancer therapeutics, medical microrobots, translational research, tissue engineering, and advanced nanomaterials.

She previously served as an INSPIRE Faculty Fellow at the Indian Institute of Science, where she developed innovative biomedical devices, and later co-founded MagHeals Private Limited to translate her research into clinical applications.

Her work has been supported by prestigious grants, including the BIG BIRAC grant and the INSPIRE Faculty Award, and she has published in leading international journals such as Biomaterials, Carbon, Nanoscale, and Hyperthermia.

 

  • Doctor of Philosophy, Materials Science and Engineering, Indian Institute of Technology, Kanpur, Uttar Pradesh, India
  • Master of Technology, Materials Science and Technology, Indian Institute of Technology, BHU, Varanasi, UP, India
  • Master of Science in Physics, School of Studies Physics (specialization Materials Science), Jiwaji University, Gwalior, MP, India

Corresponding Author

  1. Magneto-conducting multifunctional Janus microbots for intracellular delivery of biomolecules. Sachin Latiyan, Kaushik Suneet and Shilpee Jain*. Journal of Tissue Engineering and Regenerative Medicine (IF 3.9, citations 2) 2021. 15, p. 625-633.
  2. Magnetic nanofibers based bandage for skin cancer treatment: a non-invasive hyperthermia therapy. Kaushik Suneet, Tamasa De, Annapoorni Rangarajan and Shilpee Jain*. Cancer Reports (IF 1.7, citations 24) 2020. 3, e1281.
  3. Magnetic hyperthermia adjunctive therapy for fungi: in vitro studies against Candida albicans. Kaushik Suneet, Shreyas Sridhar, Purvi Agiwal, Mittanamalli S Sridhar, Kaustuv Sanyal and Shilpee Jain*; International Journal of Hyperthermia (IF 3.9, citations 6) 2019. 36, p. 545-553.
  4. Chitosan−Glycerol Gel as Barrier Formulation for Metal Allergy. Venkata Subramanian Ramesan and Shilpee Jain*; ACS Omega (IF 3.5, citations 6) 2019. 4, p. 5900-5903.
  5. The combined effect of thermal and chemotherapy on HeLa cells using a magnetically actuated smart textured fibrous system. Pranav Tiwari, Sakshi Agarwal, Sachchidanand Srivastava and Shilpee Jain*; Journal of Biomedical Materials Research, Part B Applied Biomaterials (IF 3.3, citations 15) 2018. 106, p. 40-51.
  6. Study of smart antibacterial PCL-xFe3O4 thin films using mouse NIH-3T3 fibroblast cells in vitro. Ganesh Pai, Ajay V Kulkarni and Shilpee Jain*; Journal of Biomedical Materials Research, Part B Applied Biomaterials (IF 3.3, citations 9) 2017. 105, p. 795–804.

Co-author

  1. Synthesis of Graphene oxide-Fe3O4 based nanocomposites using the mechanochemical method and in vitro magnetic hyperthermia. Aleksandr S. Kamzin, Bashar Issa, Venkatesha Narayanaswamy, Shilpee Jain, Sachin Latiyan, Chandan Srivastava, Hemant Kumar and Ihab M. Obaidat; International Journal of Molecular Sciences (IF 4.1, citations 44) 2019. 20, p.3368-3380.
  2. Remarkably selective biocompatible turn-on fluorescent probe for detection of Fe3+ in human blood samples and cells. Vishaka V H, Manav Saxena, Geetha Balakrishna R, Sachin Latiyan, Shilpee Jain; RSC Advances (IF 3.3, citations 20) 2019. 9, p. 27439-27448.
  3. A composite of hyaluronic acid modified graphene oxide and iron oxide nanoparticles for targeted drug delivery and magneto-thermal therapy. Nilkamal Pramanik, Santha Laxmi, Sunaina Rao, Kaushik Suneet, Shilpee Jain, Annapoorni Rangarajan and Siddharth Jhunjhunwala; ACS Omega (IF 3.5, citations 52) 2019. 4, p. 9284−9293.
  4. The Role of interface quality in iron oxide core/shell nanoparticles on heating efficiency and transverse relaxivity. Venkatesha Narayanaswamy, Ihab M Obaidat, Sachin Latiyan, Shilpee Jain, Chiranjib Nayek, Sumana Goankar, M-Ali AL-Akhras, and Imaddin A. Al-Omari; Materials Express (IF 1.5, citations 9) 2019. 9, p. 328-336.
  5. Single coating of zinc ferrite renders magnetic nanomotors therapeutic and stable against agglomeration. Pooyath Lekshmy Venugopalan, Shilpee Jain, Srinivasrao Shivashankar and Ambarish Ghosh; Nanoscale (IF 7.7, citations 38) 2018. 10, p. 2327-2332.
  6. Vertical electric field induced bacterial growth inactivation on amorphous carbon electrodes. Shilpee Jain, Ashutosh Sharma and Bikramjit Basu; Carbon (IF 9.5, citations 20) 2015. 81, p. 193-202.
  7. Vertical electric field stimulated neural cell functionality on porous amorphous carbon electrodes. Shilpee Jain, Ashutosh Sharma and Bikramjit Basu; Biomaterials (IF 10.3, citations 59) 2013. 34, p. 9252-9263.
  8. Intracellular reactive oxidative stress, cell proliferation and apoptosis of Schwann cells on carbon nanofibrous substrates. Shilpee Jain, Thomas J Webster, Ashutosh Sharma and Bikramjit Basu; Biomaterials (IF 10.3, citations 46) 2013. 34, p. 4891-4901.
  9. Patterned growth and differentiation of neural cells on polymer-derived carbon substrates with micro/nanostructures in vitro. Jaba Mitra,* Shilpee Jain,* Ashutosh Sharma and Bikramjit Basu; Carbon (IF 9.5, citations 54) 2013. 65, p. 140-155. (*Equal contribution)
  10. In vitro cytocompatibility assessment of amorphous carbon structures using neuroblastoma and Schwann cells. Shilpee Jain, Ashutosh Sharma and Bikramjit Basu; Journal of. Biomedical Materials Research Part B (IF 3.3, citations 41) 2013. 101B, p. 530-531.

Patent

  1. A high-frequency magnetic induction device for the treatment of oral cancer, priority # 202241022075 (IN), PCT/IB2023/060354, Oct 2023.

Book Chapters

  1. Functionalized magnetic nanoparticles for treating bone diseases. Shilpee Jain, Neelima Mahato and Alok Kumar. Nanomedicine – second edition, Edited by Dr. Thomas Webster, Woodhead Publishing Series in Biomaterials, 2023, p59-79.
  2. Magnetic properties of 2-D Materials, Rajesh Katoch and Shilpee Jain, CRC Press; 2022, p 95-122.

Book Review

  1. The review of the book entitled ‘Dielectric Relaxation in Biological
    Systems: Physical Principles, Methods, and Applications’ edited by
    Valerica Raicu and Yuri Feldman, published in Current Science, Vol. 110, No. 6, 25 March 2016.

  • BIG BIRAC Grant, September 2021, for 18 months, INR 50 Lakh
  • DST INSPIRE Faculty Award June 5, 2014 to June 4, 2019, INR 35 Lakh grant money.

  • BIG BIRAC Award, September 2021
  • DST INSPIRE Faculty Fellowship, December 2013
  • DST International Travel Grant to attend APS March Meeting, Denver, Colorado, US (02 March- 07 March 2013)
  • IUSSTF scholarship for US visit (20 May 2011 to 20 Aug 2011)
  • 1st prize in SEM section, Micrography Contest 2011, IIT Kanpur, Kanpur, India
  • Best presentation award in Departmental postgraduate seminar, 2010
  • Research assistantship, MHRD, India, 2007-2013
  • Life membership of the Indian Association for Hyperthermia Oncology and Medicine Society

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