Chanakya University > Faculty > Faculty > Dr. H.S. Subramanya

Dr. H.S. Subramanya

School of Biosciences
Dean, School of Biosciences
Ph.D Indian Institute of Science, Bangalore, Post-doc, Oxford University, UK
Former Director, IBAB, Bengaluru

Prof H.S. Subramanya is a distinguished scientist with a strong academic background and extensive experience in research and industry spanning across three decades. He is a renowned expert in Structural biology and Drug research. 

He obtained his doctoral degree (PhD) from Indian Institute of Science, Bengaluru, India and his thesis was on ‘Structure of Sesbania Mosaic Virus at 4.7Ao resolution”. He completed his Post-doc at Oxford University, UK where he has extensively worked on the biochemical and structural aspects of enzymes belonging to the DNA replication pathway. 

He has also served as Assistant Director at Central drug research institute (CDRI), Lucknow, India. He has over 20 years of experience in drug discovery platform at Aurigene Discovery Technologies Ltd., Bengaluru, India where he served in multiple capacities as director, Vice president and Senior Vice President. He has also served as the Director of Institute of Bioinformatics and Applied Biotechnology (IBAB). He has over 50 peer-reviewed publications and 19 patents to his credit. 

Publications 

  1. Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family Aishwarya H. Arole, Prashant Deshmukh, Ashok Sridhar, Shruti Mathur, Mahesh Mahalingaswamy, Hosahalli Subramanya, Nandakumar Dalavaikodihalli Nanjaiah and Balasundaram Padmanabhan Acta Cryst. (2023). D79, 758–774.

  2. Profilin is involved in G1 to S phase progression and mitotic spindle  orientation during Leishmania donovani cell division cycle Ambaru B, Gangadharan G M, Subramanya H S, Gupta CM PLOS ONE, 17(3), 2022

  1. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. Ramulu Poddutoori, Kimberly Aardalen, Kiran Aithal, Sanjeev Surendranath Barahagar, Charamanna Belliappa, Mark Bock, Shekar Chelur, Andrea Gerken, Sreevalsam Gopinath, Bjoern Gruenenfelder, Michael Kiffe, Maithreyi Krishnaswami, John Langowski, Sudharshan Madapa, Kishore Narayanan, Chetan Pandit, Sunil Kumar Panigrahi, Mark Perrone, Ravi Kumar Potakamuri, Murali Ramachandra, Anuradha Ramanathan, Rita Ramos, Emine Sager, Susanta Samajdar, Hosahalli S Subramanya, Devaraja Seethappa Thimmasandra, Eleni Venetsanakos, Henrik Möbitz Journal of Medicinal Chemistry 65 (5), 4350-4366 (2022)

  1. Draft genome sequence of the community-associated staphylococcus aureus sequence type 88 strain LVP-7, isolated from an ocular infection Savitha Nadig, Sneha Murthy, Muralidharan Vandanashree, Hosahalli S Subramanya, Balasubramanian Gopal, Shruthi Vembar Microbiology Resource Announcements 10 (7), e00077-21 (2021)

  2. Whole Genome Sequences of Aedes aegypti (Linn.) Field Isolates from Southern India. Bernard, V, Moudgalya, S, Reegan, D, Sreekanthreddy, P, Mohan, A, Subramanya, H S, Vembar, S S, Ghosh, S. BioRxiv. (2020)

  3. Actin sequestering protein, profilin, regulates intracellular vesicle transport in Leishmania Ambaru B, Gopalsamy A, Tammana TVS, Subramanya HS, Gupta CM Molecular & Biochemical Parasitology 238, 111280 (2020)

  1. Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis S Kumari, HS Subramanya BMC Research Notes 13 (1), 1-5 (2020)

  1. Selective vulnerability to pyrimidine starvation in hematologic malignancies revealed by AG-636, a novel clinical-stage inhibitor of dihydroorotate dehydrogenase Gabrielle McDonald, Victor Chubukov, John Coco, Kevin Truskowski, Rohini Narayanaswamy, Sung Choe, Mya Steadman, Erin Artin, Anil K Padyana, Lei Jin, Sebastien Ronseaux, Charles Locuson, Zi-Peng Fan, Tabea Erdmann, Alan Mann, Sebastian Hayes, Mark Fletcher, Kavitha Nellore, Siva Sanjeeva Rao, Hosahalli Subramanya, K Satish Reddy, Sunil K Panigrahi, Thomas Antony, Sreevalsam Gopinath, Zhihua Sui, Nelamangala Nagaraja, Lenny Dang, Georg Lenz, Jonathan Hurov, Scott A Biller, Josh Murtie, Kevin M Marks, Danielle B Ulanet Molecular Cancer Therapeutics 19 (12), 2502-2515 (2020)

  1. Discovery of CA-4948, an orally bioavailable IRAK4 inhibitor for treatment of hematologic malignancies Venkateshwar Rao Gummadi, Anima Boruah, Bharathi Raja Ainan, Brahma Reddy Vare, Srinivas Manda, Hari Prakash Gondle, Shiva Nagendra Kumar, Subhendu Mukherjee, Suraj T Gore, Narasimha Rao Krishnamurthy, Sivapriya Marappan, Shilpa S Nayak, Kavitha Nellore, Wesley Roy Balasubramanian, Archana Bhumireddy, Sanjeev Giri, Sreevalsam Gopinath, Dodheri S Samiulla, Girish Daginakatte, Aravind Basavaraju, Shekar Chelur, Rajesh Eswarappa, Charamanna Belliappa, Hosahalli S Subramanya, Robert N Booher, Murali Ramachandra, Susanta Samajdar ACS medicinal chemistry letters 11 (12), 2374-2381 (2020)

  1. India Needs More Policy Research HS Subramanya, G Saberwal Current Science 116 (8), 1279-1280 (2019)

  1. Some data quality issues at Clinical Trials. Gov Chaturvedi, N., Mehrotra, B., Kumari, S. Gupta, S Subramanya HS, & Saberwal G Trials 20, 378 (2019)

  2. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells A.K. Mohamad Fairus, B. Choudhary, S. Hosahalli, N. Kavitha, O. Shatrah Biochimie, 135:154-163 (2017)

  1. Dihydroorotate dehydrogenase inhibitors target c-Myc and arrest melanoma, myeloma and lymphoma cells at S-phase MS Dorasamy, B Choudhary, K Nellore, H Subramanya, PF Wong Journal of Cancer 8 (15), 3086 – 3098 (2017)

  1. Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Iskandar Abdullah, Chin Fei Chee, Yean-Kee Lee, Siva Sanjeeva Rao Thunuguntla, K Satish Reddy, Kavitha Nellore,Thomas Antony, Jitender Verma, Kong Wai Mun, Shatrah Othman, Hosahalli Subramanya, Noorsaadah Abd Rahman Bioorg Med Chem, 2015 Aug 5;23 (15): 4669-80.

  1. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei—Crystal structure, mode of action, and biological activity Narasimha Rao, K., Lakshminarasimhan, A., Joseph, S., Lekshmi, S. U., Lau, M.- S., Takhi, M., Sreenivas, K., Nathan, S., Yusof, R., Abd. Rahman, N., Ramachandra, M., Antony, T. and Subramanya, H. Protein Science, 2015, 24, 832–840.

  1. Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach. Rajeev Goswami, Gerd Wohlfahrt, Subhendu Mukherjee, Chakshusmathi Ghadiyaram, Jwala Nagaraj, Leena K Satyam,Krishnaprasad Subbarao, Sreevalsam Gopinath, Narasimha R Krishnamurthy, Hosahalli S Subramanya, Murali Ramachandra Bioorg. Med. Chem. Lett. 2015 Feb 17, 25(3), 616-20

  1. X-ray structure of PTP1B in complex with a new PTP1B inhibitor. M V V V Sekhar Reddy, Chakshumathi Ghadiyaram, Sunil Kumar Panigrahi, Narasimha Rao Krishnamurthy, Subramanya Hosahalli, Arun P Chandrasekharappa, Deepankar Manna, Sangamesh E Badiger, Pramod K Dubey, Lakshmi Narasu Mangamoori Protein Pept Lett., 2014 ;21(1):90-3

  1. Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitor. Mohamed Takhi, Kandepu Sreenivas, Chandrashekar K. Reddy, Mahadari Munikumar, Kolakota Praveena, Pabolu Sudheer, Bandaru N.V.M. Rao, Gollamudi Ramakanth, Jampala Sivaranjani, Shardaprasad Mulik, Yeruva R. Reddy, Krishnamurthy Narasimha Rao, Rentala Pallavi, Anirudha Lakshminarasimhan, Sunil K. Panigrahi, Thomas Antony, Iskandar Abdullah, Yean K. Lee, Murali Ramachandra, Rohana Yusof, Noorsaadah A. Rahman, Hosahalli Subramanya European Journal of Medicinal Chemistry, Volume 84, 12 September 2014, Pages 382-394.

  1. A facile synthesis of 7,12-dihydro-1,3,6,7,12-pentaazapleiadenes by domino reaction Vishnu Basetti, Rangarao Pallepati, Emima Thadi, Subramanya Hosahalli and Vijay Potluri Heterocycl. Commun. 2014; 20(4): 207–214

  1. Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Rajeev Goswami, Subhendu Mukherjee, Chakshusmathi Ghadiyaram, Gerd Wohlfahrt, Ramesh K Sistla, Jwala Nagaraj, Leena K Satyam, Krishnaprasad Subbarao, Rajendra K Palakurthy, Sreevalsam Gopinath, Narasimha R Krishnamurthy, Tarja Ikonen, Anu Moilanen, Hosahalli S Subramanya, Pekka Kallio, Murali Ramachandra Bioorg Med Chem 2014 Jun 18;22(12):3187-203.

  1. Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors Rajeev Goswami, Subhendu Mukherjee, Gerd Wohlfahrt, Chakshusmathi Ghadiyaram, Jwala Nagaraj, Beeram Ravi Chandra, Ramesh K. Sistla, Leena K Satyam, Dodheri S. Samiulla, Anu Moilanen, Hosahalli S. Subramanya, and Murali Ramachandra ACS Med. Chem. Lett., 2013, 4 (12), pp 1152–1157

  1. Diphenylether derivative as selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) over t-cell protein tyrosine phosphatase (TCPTP) identified through virtual screening. Reddy MV1, Ghadiyaram C, Panigrahi SK, Hosahalli S, Mangamoori LN Mini Rev Med Chem. 2013 Oct; 13 (11):1602-6

  1. Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode Venkateshwar Rao Gummadi, Sujatha Rajagopalan, Looi Chung Yeng, Mohammadjavad Paydar, Girish Aggunda Renukappa, Bharathi Raja Ainan, Narasimha Rao Krishnamurthy, Sunil Kumar Panigrahi, Kumari Mahasweta, Sangeeth Raghuramachandran, Manoj Rajappa, Anuradha Ramanathan, Anirudha Lakshminarasimhan, Murali Ramachandra, Wong Pooi Fong, Mohammad Rais Mustafa, Srinivas Nanduri, Subramanya Hosahalli Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 17, 1 September 2013, Pages 4911–4918

  2. A facile synthesis of tetracyclic benzo-pyridonaphthyridines by domino reaction Vishnu Basetti, Rangarao Pallepati, Subramanya Hosahalli and Vijay Potluri Tetrahedron Letters, Volume 54, Issue 15, 10 April 2013, Pages 2014-2017

  1. A structure-based strategy for new drug discovery. Ramesh S, Chakshusmathi G, Nagaraja CS and Subramanya, H.S. (2006)IPT 20, 18.

  1. Role of Lys-226 in the Catalytic Mechanism of Bacillus stearothermophilus Serine Hydroxymethyltransferase – Crystal Structure and Kinetic Studies. Bhavani S, Trivedi V, Ambili M, Jala VR, Subramanya, H.S, Purnima, K, Prakash, V, Appaji Rao, N, Savithri, H. S. (2005)Biochemistry, 44, 6929-37.

  1. Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya, H.S. and RajBhandary UL (2004).Nucleic Acids Res., 32, 1018-27.

  1. Structure-function relationship in serine hydroxymethyltransferase.Appaji Rao N, Ambili M, Jala VR, Subramanya, H.S. and Savithri HS (2003).Biochim Biophys Acta., 1647, 24-9.

  1. Different unfolding pathways for mesophilic and thermophilic homologues of serine hydroxymethyltransferase.Bhatt AN, Prakash K, Subramanya H.S. and Bhakuni V. (2002).Biochemistry, 41, 12115-23.

  1. Crystal Structure of Binary and Ternary Complexes of Serine Hydroxymethyl- transferase from B.stearothermophilus: Insights into the Catalytic Mechanism. Trivedi, V., Gupta, A., Rao, J.V.K., Saravanan, P., Rao, G.S.J., Rao, A.N., Savithri,H.S. and Subramanya, H.S. (2002).J. Biol. Chem, 277, 17161-69.

  1. Purification and Crystallization of CII: An unstable Transcription Activator from Phage lambda.Datta B., Chakrabarti, P., Subramanya, H.S., and Parrack, P. (2001).Biochem. Biophys. Res. Commun. 288, 997-1000.

  1. Crystal Structure of Rv2118c: An AdoMet-dependent Methyltransferase from Mycobacterium tuberculosis H37Rv. Gupta, A., Hari Kumar, P., Dineshkumar, T.K., Varshney, U. and Subramanya, H.S.(2001).J. Mol. Biol. 312, 381-391.

  2. Dysobinin, a tetranortriterpenoid. Sarkhel S, Jain GK, Singh S, Subramanya, H.S., Maulik PR. (2000). Acta Crystallogr C., 56, E253-4.

  1. Three-Dimensional quantitative structural activity relationship (3D-QSAR) studies of some 1,5-Diarylpyrazoles: Analogue based design of selective Cyclooxygenase-2 Inhibitors. Desiraju, G.R., Gopalakrishnan, B., Jetti, R.K.R., Raveendra, D., Sarma, J.A.R.P. and Subramanya, H.S. (2000). Molecules, 5, 945-955.

  1. Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Velankar, S.S., Soultanas, P., Dillingham, M.S., Subramanya, H.S. and Wigley, D.B. (1999).Cell, Vol. 97, 75-84.

  1. Characterization of Bacillus stearothermophylus PcrA helicase: Evidence against an active rolling model.Bird, L.E., Brannigan, J.A., Subramanya, H.S. and Wigley, D.B. (1998).Nucl. Acids Res. 26, 2686-2693.

  1. Helicases: A unifying structural theme? Bird, L.E., Subramanya, H.S. and Wigley, D.B. (1998).Curr. Opin. Struc. Biol., 8, 14-18.

  1. Crystal structure of the site specific recombinase XerD. Subramanya, H.S., Arciszewska, L.K., Baker, R., Bird, L.E., Sherrat, D.J. and Wigley, D.B. (1997). EMBO J., 16, 5178-5187.

  1. Structure of sesbania mosaic viruses at 3 Å resolution. Murthy, M.R.N., Bhuvaneswari, M., Subramanya, H.S., Gopinath, K., Savithri, H.S. (1997) Biophys. Chem., Vol. 68, 33-42.

  1. Architecture of small RNA viruses. Bhuvaneswari, M., Subramanya, H.S., Murthy, M.R.N., Gopinath, K. and Savithri, H.S. (1997). Prog. Crystal Growth and Charact., Vol. 34, 1-10.

  1. Crystallization and preliminary crystallographic analysis of the DNA gyrase B protein from B. stearothermophilus. Tsai, F.T.F., Subramanya, H.S., Brannigan, J.A. and Wigley, D.B. (1996). Acta Cryst., 1216-1218.

  1. Crystal structure of a Dexx box DNA helicase. Subramanya, H.S., Bird, L.E., Brannigan, J.A. and Wigley, D.B. (1996). Nature, 384, 379-383.

  1. Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Subramanya, H.S., Doherty, A.J., Ashford, S.R. and Wigley, D.B. (1996). Cell, 85, No.4, 607-615.

  1. Bacteriophage T7 DNA ligase: Overexpression, purification, crystallization and characterization. Doherty, A.J., Ashford, S.R., Subramanya, H.S. and Wigley, D.B. (1996). J. Biol. Chem, 271, 11083-11089.

  1. Preliminary crystallographic analysis of the ParE subunit of E.coli topoisomerase IV. Subramanya, H.S., Peng, H., Marians, K.J. and wigley, D.B. (1996). Acta Cryst., D52, 579-580.

  1. Enzymatic ketonization of 2-hydroxymuconate: Specificity and mechanism investigated by the crystal structure of two isomerases. Subramanya, H.S., Roper, D.I., Dauter, Z., Dodson, E.J., Davis, G.J., Wilson, K.S. and Wigley, D.B. (1996). Biochemistry, 35, 792-802.

  1. Structure of sesbania mosaic virus at 3 Å resolution. Bhuvaneswari, M., Subramanya, H.S., Gopinath, K., Savithri, H.S., Nayudu, M.V. and Murthy, M.R.N. (1995). Structure, Vol. 3, No. 10, 1021-1030.

  1. Structure of sesbania mosaic virus at 4.7 Å resolution. Subramanya, H.S. (1995) J. Indian Inst. Sci., 75, 720-722

  1. Preliminary crystallographic analysis of 4-oxalocrotonate tautomerase reveals the oligomeric structure of the enzyme. Roper, D.I., Subramanya, H.S., Shingler, V. and Wigley, D.B. (1994). J. Mol. Biol. 243, 799-801

  1. Structure of sesbania mosaic virus at 4.7 Å resolution and partial sequence of the coat protein. Subramanya, H.S., Gopinath, K., Nayudu, M.V., Savithri, H.S. and Murthy, M.R.N. (1993) J.Mol.Biol 229, 20-25.

Patents 

  1. Azine Compounds as Glucokinase Activators (2009)
    SE Badiger, KF Fosgerau, N Vrang, VD Chaudhari, JJ Naik, J Auxcilia, RR Reddy, HS Subramanya, PV Reddy, BNS Reddy,
    WO2009/083553A1

  2. Hetereocyclic Compounds as MEK Inhibitors (2010)
    D Chikkanna, C McCarthy, H Moebitz, C Pandit, R Sistla, H Subramanya
    WO/2010/121646

  3. Piperazine derivatives as inhibitors of stearoyl-CoA desaturase (2011)
    K Sundaresan, SN Raikar, SR Sammeta, G Prabhu, H Subramanya, A Bischoff
    US Patent 8,039,463

  4. Piperidine derivatives as inhibitors of stearoyl-CoA desaturase (2012)
    K Sundaresan, PBK Rao, B Ainan, H Ayyamperumal, AR Girish, S Tatiparthy, G Prabhu, H Subramanya, A Bischoff
    US Patent 8,129,376

  5. Substituted quinazoline and pyrido-pyrimidine derivatives (2012)
    RA Smith, SK Thompson, S Hosahalli, M Bejugam, S Nanduri, P Sunil Kumar, M Natarajan
    WO/2012/058671

  6. Isoxazolines as therapeutic agents (2012)
    DJ Calderwood, EC Breinlinger, SL Swann, VS Chitty, S Hosahalli
    WO/2012/151158

  7. Substituted pyridine derivatives as FABI inhibitors (2013)
    M Takhi, S Hosahalli, SK Panigrahi, MK Mahadari, CR Kottam, N Abd Rahman, R Yusof
    WO/2013/080222

  8. Bicyclic Heterocycles as IRAK4 Inhibitors (2013) A Boruah, HS Subramanya, S Mukherjee WO/2013/042137

  9. Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors (2014)
    SSR Thunuguntla, S Hosahalli, SR Kunnam
    WO/2014/128669

  10. Tetrahydropyridine derivatives as FabI inhibitors (2015) M Takhi, S Hosahalli, SK Panigrahi
    WO/2014/195844

  11. Dihydroorotate Dehydrogenase Inhibitors (2015)
    SSR Thunuguntla, H Subramanya, SR Kunnam, SRS Vijay, C Bingi, R Kusanur, M Schwarz, M Arlt
    US9006454B2

  12. Bicyclic heterocycle derivatives as bromodomain inhibitors (2015) S Samajdar, C Abbineni, S Sasmal, S Hosahalli
    WO2015104653A1

  13. Substituted amino-pyrimidine derivatives (2015)
    RA Smith, A Venkatesan, M Bejugam, S Hosahalli, S Nanduri
    US 9145411B2

  14. 3-(pyrazolyl)-1H-pyrrolo [2, 3-b] pyridine derivatives as kinase inhibitors (2016) VR Gummadi, S Hosahalli, S Nanduri, GA Renukappa
    US Patent 9,353,107

  15. Crystalline Structure of FABI from Burkholderia Pseudomallei (2017) NR Krishnamurthy, A Lakshminarasimhan, T Antony, HS Subramanya
    US20170088822A1

  16. Quinazolines and azaquinazolines as dual inhibitors of RAS/RAF/MEK/ERK and PI3K/AKT/PTEN/mTOR pathways
    SK Thompson, RA Smith, S Reddy, TM John, VK Nyavanandi, S Hosahalli, V Potluri, SK Panigrahi, PR Nadipalli, S Sengupta (2019)
    US Patent 10,226,468

  17. Pyrimido-pyridazinone compounds and methods of use thereof (2019)
    A Venkatesan, RA Smith, H Subramanya, V Potluri, SK Panigrahi, V Basetti, K Kunta
    US Patent 10,183,944

  18. 1, 4, 6-trisubstituted-2-alkyl-1H-benzo [d] imidazole derivatives as dihydroorotate oxygenase inhibitors (2020)
    SSR Thunuguntla, S Hosahalli, SK Panigrahi, M Schwarz, M Arlt (2020)
    WO2018154088A1

  19. Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors (2021)
    K Nellore, S Hosahalli WO2018197997A1