
Dr. Abrar Rizvi
Ph.D., FIRC Institute of Molecular Oncology, University of MilanResearch Scientist, School of Bioscience
Dr. Abrar Rizvi
Ph.D., FIRC Institute of Molecular Oncology, University of MilanMy primary research interest lies in studying the restoration of tissue homeostasis at the intersection of development, repair and regenerative processes. These processes can become aberrant during pathological conditions and cause diseases like chronic wounds, fibrosis or tumours. Using the knowledge of the fundamental processes in restoration of tissue homeostasis, we aim to translate our findings into novel therapeutics to combat fibrotic diseases and tumorigenesis.
Abrar Rizvi has taught at Chanakya University’s School of Biosciences since 2024. He is interested in Molecular Biology, Immunology, Cell and Tissue Biology.
He was a DST-SERB National postdoctoral fellow at Institute for Stem Cell Science and Regenerative Medicine (inStem), Bangalore, where he has studied the mechanisms of fibroblast activation and ECM secretion during tissue repair and fibrosis. He been part of the widely cited research work on wound healing and fibrosis.
During his PhD, Abrar studied the mechanism of polarity establishment and lumen morphogenesis using in vitro 3-D tissue culture models as well as small animal models. He has published about the role of IRSp53 as an early determinant of epithelial polarity and lumen morphogenesis in his Nature Communications article.
Abrar Rizvi teaches Cell Biology and Immunology in the core curriculum at the School of Biosciences.
- Ph.D., 2019, FIRC Institute of Molecular Oncology, University of Milan
- M.Sc. Biotechnology, 2011, The University of Kashmir
- B.Sc., 2008, The University of Kashmir
- Kataria S, Rana I, Badarinath K, Zaarour RF, Kansagara G, Ahmed S, Rizvi A, Saha D, Dam B, Dutta A, Zirmire RK, Hajam EY, Kumar P, Gulyani A, Jamora C. Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis. JCI Insight. 2024 Dec 31;10(3):e173071. doi: 10.1172/jci.insight.173071.
- Rana I, Kataria S, Tan TL, Hajam EY, Kashyap D, Saha D, Ajnabi J, Paul S, sjayappa; Ananthan AS, Kumar P, Zaarour R, Jayaprakash H, Kansagara G, Rizvi A, Zirmire RK, Badarinath K, Khedkar S, Yogesh C, Samuel R, George R, Danda D, Jacob PM, Dey R, Perundurai D, He YW, Varga J, Varghese S, Jamora C. Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis. Journal of Investigative Dermatology, Volume 143, Issue 5, 2023. DOI:10.1016/j.jid.2022.10.011
- Zaarour RF, Saha D, Dey R, Dutta A, Kumar P, Rana I, Pulianmackal A, Rizvi A, Misra N, Breton L and Jamora C. The neuropeptide Substance P facilitates the transition from an inflammatory to proliferation phase-associated responses in dermal fibroblasts. Exp Dermatol; March 2022. DOI:10.1111/exd.14573
- Bisi S*, Marchesi S*, Rizvi A*, Carra D, Beznoussenko G, Ferrara I, Deflorian G, Mironov A, Bertalot G, Pisati F, Oldani A, Cattaneo A, Saberamoli G, Pece S, Viale G, Bachi A, Tripodo C, Disanza A and Giorgio S. IRSp53 shapes the plasma membrane and controls polarized transport at the nascent lumen during epithelial morphogenesis. Nature Comm; July 2020. DOI:10.1038/s41467-020-17091-x (*Equal contribution)
- Bhatt T, Mruthyunjaya MS, Aishwarya B, Bhavya B, Rizvi A, Giorgio S, Amitabha M and Jamora C. Sustained Secretion of the Antimicrobial Peptide S100A7 Is Mediated by the Wound Healing Machinery. Cell Reports; Nov 2019. DOI:10.2139/ssrn.3322364
- Disanza A, Bisi S, Frittoli E, Malinverno C, Marchesi S, Palamidessi A, Rizvi A and Giorgio S. Opinion Piece: Is cell migration a selectable trait in the natural evolution of cancer development? Philosophical Transactions B; July 2019. DOI:10.1098/rstb.2018.0224
- Bhatt T, Rizvi A, Batta SPR, Kataria S and Jamora C. Signaling and mechanical roles of E-cadherin. Cell Communication & Adhesion; 2013 Dec; 20(6):189-99. DOI:10.3109/15419061.2013.854778
Project 1
- Title: Role of PCBP-1in magnetic nanoparticle induced hyperthermic cell death
- PI: Abrar Rizvi & Shilpee Jain
- Status: Ongoing
Project 2
- Title: Structure-Function Analysis of Mindin
- PI: Abrar Rizvi
- Status: Ongoing
Project 3
- Title: A novel therapeutic approach against fibrotic diseases
- Duration: 2 years
- Granting Agency: DST-SERB
- PI: Abrar Rizvi/Co-PI: Colin Jamora
- Purpose: Research study on developing anti-fibrotic therapeutics
- Status: Completed
- Grant Amount: INR 23,36,800
Project 4
- Title: Screening for Mindin inhibitors for potential therapeutics against fibrotic diseases
- Duration: 18 Months
- Granting Agency: DBT-BIRAC
- PIs/Co PIs: Abrar Rizvi
- Purpose: Development of Screening platform for discovery of novel drug molecules against fibrosis
- Status: Completed
- Grant Amount: INR 50L
- 2022 DST-SERB National Postdoctoral Fellowship
- 2014 FUV fellowship
- GATE-2011
- ICMR JRF 2011
- CSIR-UGC JRF 2011 & 2010
- CSIR-UGC NET 2010
- Abrar Rizvi is also a visiting scientist at National Centre for Biological Sciences (NCBS), Bangalore and Founder-Director of Matriverse Pvt. Ltd.