New Publication by Dr Krishna’s Research Group

Dr Krishna Kurthkodi and his team have published a research article in Frontiers in Cellular and Infection Microbiology journal, titled, “Expression of dnaE2 promotes genetic diversity in mycobacterial biofilms”. 

Figure legend. Mutagenesis and bacterial growth arrest by dnaE2 expression in biofilm.
Biofilm formation is initiated by the attachment of mycobacteria to a substratum. During maturation, an extracellular matrix encloses a heterogeneous population of dead bacteria (red), growth-arrested bacteria (blue), and mutant bacteria (green) generated by reduced DNA repair and induction of the error-prone polymerase DnaE2. Growth arrest within the subpopulation emerges from the conflict between DnaE2 and the housekeeping DnaE1. During the reactivation of biofilm to planktonic growth, the expression of DnaE2 is repressed, and the balance of polymerases shifts in favour of DnaE1, resulting in active multiplication.